Investigation on the association between serum lipid levels and periodontitis: a bidirectional Mendelian randomization analysis.

ABSTRACT:

Objective

Several research has considered the potential correlation between periodontitis and serum lipids. However, serum lipid profiles correlation with periodontitis remains largely unknown. The investigation objective was to examine periodontitis correlation with serum lipid levels using a bidirectional Mendelian randomization (MR) analysis.

Methods

The study employed a bidirectional MR analysis with two samples, utilizing a freely accessible genome-wide association study (GWAS). Furthermore, the primary analysis employed the inverse variance weighted (IVW) method. To determine whether the lipid profiles were associated with periodontitis, a variety of sensitivity analyses (including MR-Egger regression, MR-PRESSO, and weighted median), as well as multivariable MR, were

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10623747 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature