L-shaped association of serum α-Klotho and frailty among the middle-aged and older adults: results from NHANES 2007-2016.

ABSTRACT:

Background

Frailty is common and not limited to older age group. Serum α-Klotho works as a biomarker of anti-aging effect. However, there is limited research about the relationship between them in middle-aged and older people and controversy still exists.

Methods

Based on data from National Health and Nutrition Examination Survey (NHANES) 2007-2016, we constructed weighted logistic regression models and conducted sensitivity tests to investigate the correlation between frailty and α-Klotho among people aged 40 to 79. And then their relationship was visualized by Restricted Cubic Spline (RCS). Finally, the stratified analyses and interaction tests of covariables was presented in the forest plot.

Results

A total of 7052 individuals were involved in this study, with mean

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10623765 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature