P38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling. Although the abnormalities are primarily prompted by chronic exposure to inhaled irritants, maladjusted and self-reinforcing immune responses are significant contributors to the development and progression of the disease. The p38 isoforms are regarded as pivotal hub proteins that regulate immune and inflammatory responses in both healthy and disease states. As a result, their inhibition has been the subject of numerous recent studies exploring their therapeutic potential in COPD.

Main body

We performed a systematic search based on the PRISMA guidelines to find relevant studies about P38 signaling in COPD

SUBMITTER: Ahmadi A 

PROVIDER: S-EPMC10623820 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature