Multiomics analysis reveals the genetic and metabolic characteristics associated with the low prevalence of dental caries.

ABSTRACT:

Background

Despite poor oral hygiene, the Baiku Yao (BKY) ethnic group in China presents a low prevalence of dental caries, which may be related to genetic susceptibility. Due to strict intra-ethnic marriage rule, this ethnic has an advantage in studying the interaction between genetic factors and other regulatory factors related to dental caries.

Methods

Peripheral blood from a caries-free adult male was used for whole genome sequencing, and the BKY assembled genome was compared to the Han Chinese genome. Oral saliva samples were collected from 51 subjects for metabolomic and metagenomic analysis. Multiomics data were integrated for combined analysis using bioinformatics approaches.

Results

Comparative genomic analysis revealed the presence of structural variations i

SUBMITTER: Liu J 

PROVIDER: S-EPMC10623897 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature