Re-appraisal of the universal definition of tumor rupture among patients with high-risk gastrointestinal stromal tumors.

ABSTRACT:

Aim

Tumor rupture has been indicated as a risk factor for recurrence of gastrointestinal stromal tumors (GISTs). The universal definition of tumor rupture was proposed. This study evaluated whether the universal definition was more accurate in identification of GISTs with high recurrent risk than subjective judgment.

Methods

The study included 507 patients with high-risk GISTs who underwent complete resection between December 2012 and December 2015. We conducted a questionnaire survey in participating institutes to re-diagnose tumor rupture based on the universal definition according to their surgical and pathological findings. We compared the clinical outcomes of tumor rupture based on the definition to those based on the surgeon's judgment and clarified the clinical import

SUBMITTER: Gotohda N 

PROVIDER: S-EPMC10623932 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature