Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease.

ABSTRACT: Background: We aimed to make an integrated analysis of published transcriptome and DNA methylation dataset to ascertain the key differentially methylated and differentially expressed genes for Alzherimer's disease (AD). Methods: Two gene expression microarrays and 1 gene methylation microarray were downloaded for identification of differentially expressed genes and differentially methylated genes. Then, we used various biological information databases to annotate the functions of the differentially-methylated/expressed genes, and screen out key genes and important signaling pathways. Finally, we validate the differentially-methylated/expressed genes in the additional online datasets and in blood from AD patients.Results: A total of 8 hub hypomethylated-high expression

SUBMITTER: Qiu H 

PROVIDER: S-EPMC10624077 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature