Low Hippocampal Dentate Gyrus Volume Associated With Hypertension-Related Cognitive Impairment.

ABSTRACT: Hypertension increases the risk of cognitive impairment independent of detectable stroke or cerebral lesions. However, the principal pathophysiological basis of this increase has not been fully elucidated. The present study investigates the relationships among blood pressure, hippocampal subfields volume, and cognitive function in a relatively young non-stroke population. A total of 59 non-stroke non-dementia subjects (mean age, 57.2 ± 4.9 years) were enrolled. All subjects were subjected to complete assessment of vascular risk factors including 24-hour blood pressure monitoring, various neuropsychological tests, and 3D-T1 MR scan. Freesurfer V6.0 was used for segmentation of hippocampal subfields. Our analyses revealed that both 24-hour and daytime mean systolic blood pressure (SBP) were

SUBMITTER: Li H 

PROVIDER: S-EPMC10624078 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature