HYPER: pre-clinical device for spatially-confined magnetic particle hyperthermia.

ABSTRACT:

Purpose

Magnetic particle hyperthermia is an approved cancer treatment that harnesses thermal energy generated by magnetic nanoparticles when they are exposed to an alternating magnetic field (AMF). Thermal stress is either directly cytotoxic or increases the susceptibility of cancer cells to standard therapies, such as radiation. As with other thermal therapies, the challenge with nanoparticle hyperthermia is controlling energy delivery. Here, we describe the design and implementation of a prototype pre-clinical device, called HYPER, that achieves spatially confined nanoparticle heating within a user-selected volume and location.

Design

Spatial control of nanoparticle heating was achieved by placing an AMF generating coil (340 kHz, 0-15 mT), between two opposing permanent m

SUBMITTER: Carlton H 

PROVIDER: S-EPMC10624165 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature