RUNX1 facilitates heart failure progression through regulating TGF-β-induced cardiac remodeling.

ABSTRACT:

Background

Heart failure is caused by acute or chronic cardiovascular diseases with limited treatments and unclear pathogenesis. Therefore, it is urgent to explore new therapeutic targets and reveal new pathogenesis for heart failure.

Methods

We carried out heart failure animal model by transverse aortic arch constriction (TAC) in mice. The left ventricular internal diameter diastole (LVIDd), left ventricular internal diameter systole (LVIDs), and ejection fraction (EF) value were detected using ultrasound and myocardial fibrosis was evaluated by Masson stain assay. Cell apoptosis in myocardial tissues were detected by TUNEL immunofluorescence stain. Signal pathway analysis was performed by dual-luciferase reporter assay and western blot.

Results

Our results showed th

SUBMITTER: Qi P 

PROVIDER: S-EPMC10624168 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature