Serum cytokines MCP-1 and GCS-F as potential biomarkers in pediatric inflammatory bowel disease.

ABSTRACT:

Background

Inflammatory bowel diseases (IBDs) with the subtypes ulcerative colitis (UC) and Crohn disease (CD), are chronic autoimmune inflammatory disorders of the gastrointestinal tract. Cytokines are associated with the development and progression in pediatric IBD. We measured cytokine levels in pediatric IBD patients to assess their potential function as biomarkers in disease assessment.

Method

In this prospective cohort study, we enrolled 33 children with IBD. All patients were in stable remission for 3 months on enrollment. Patients who developed a relapse within six months after enrollment were classified as relapsers. Blood sampling was performed at enrolment and for relapsers in relapse and post-relapse. Serum concentrations of 14 cytokines, chemokines and growth fa

SUBMITTER: Ott A 

PROVIDER: S-EPMC10624322 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature