Acceleration and deceleration of chirality inversion speeds in a dynamic helical metallocryptand by alkali metal ion binding.

ABSTRACT: We report that the chirality inversion kinetics of a trinickel(II) cryptand can be controlled by guest recognition in the cryptand cavity. When the guest was absent, the nickel(II) cryptand underwent a dynamic interconversion between the P and M forms in solution, preferring the M form, with a half-life of t_1/2 = 4.99 min. The P/M equilibrium is reversed to P-favored by binding with an alkali metal ion in the cryptand cavity. The timescale of this M→P inversion kinetics was both notably accelerated and decelerated by the guest binding (t_1/2 = 0.182 min for K⁺ complex; 186 min for Cs⁺ complex); thus, the equilibration rate constants differed by up to 1000-fold depending on the guest me

SUBMITTER: Ikbal SA 

PROVIDER: S-EPMC10624348 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature