Lessons learned in translating pain knowledge into practice.

ABSTRACT:

Introduction

During the past 2 decades, basic research deciphering the underlying mechanisms of nociception and chronic pain was thought to finally step beyond opioids and nonsteroidals and provide patients with new analgesics. But apart from calcitonin gene-related peptide antagonists, nothing arrived in hands of clinicians.

Objectives

To present existing evidence of 3 representative target molecules in the development of novel pain treatment that, so far, did not result in approved drugs.

Methods

This Clinical Update aligns with the 2022 IASP Global Year Translating Pain Knowledge into Practice and selectively reviews best available evidence and practice.

Results

We highlight 3 targets: a ion channel, a neuronal growth factor, and a neuropeptide to explore wh

SUBMITTER: Becker J 

PROVIDER: S-EPMC10624476 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature