Role of fatty liver index in risk-stratifying comorbid disease outcomes in non-alcoholic fatty liver disease.

ABSTRACT:

Background & aims

Population screening for non-alcoholic fatty liver disease (NAFLD) and associated comorbidities remains an unaddressed clinical need. We aimed to assess the utility of the fatty liver index (FLI) for risk stratification of NAFLD and related comorbidities using the UK Biobank.

Methods

Electronic health records and liver MRI-proton density fat fraction (PDFF) were used to define NAFLD cases. FLI was calculated and individuals with high alcohol intake and other liver diseases were excluded. Using listwise deletion analysis, the area under receiver-operating characteristic curve (AUROC) of FLI for NAFLD risk was determined. Thereafter, time-dependent covariate-adjusted Cox regression models were used to estimate FLI's risk stratification potential for comorbidi

SUBMITTER: Ho B 

PROVIDER: S-EPMC10624587 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature