Reduction in regulatory T cells in preterm newborns is associated with necrotizing enterocolitis.

ABSTRACT:

Background

Despite multifactorial pathogenesis, dysregulation of inflammatory immune response may play a crucial role in necrotizing enterocolitis (NEC). Regulatory T cells (Tregs) are involved in immune tolerance early in life. We aimed to investigate the predicting role of Tregs in developing NEC in neonates at high risk.

Methods

We studied six newborns with a diagnosis of NEC (cases) in comparison with 52 controls (without NEC). We further classified controls as neonates with feeding intolerance (FI) and neonates without it (FeedTol). The rate of female and male neonates (sex defined as a biological attribute) was similar. We analyzed the blood frequency of Tregs (not overall numbers) at three time points: 0-3 (T0), 7-10 (T1), and 27-30 (T2) days after birth by flow cytom

SUBMITTER: Pacella I 

PROVIDER: S-EPMC10624602 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature