Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood.

ABSTRACT:

Background

Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity.

Methods

A total of 298 children from a prospective birth cohort were followed up through to age 9 years. Serum-PFAS was measured at birth and 18 months of age, while exposures during infancy were estimated by structural equations. Adiponectin, resistin, leptin, and the leptin receptor were measured in serum at age 9. Adjusted regression coefficients for estimated serum-PFAS concentrations were calculated, with additional consideration of the duration of breastfeeding and potential effect modification by sex.<

SUBMITTER: Grandjean P 

PROVIDER: S-EPMC10624607 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature