Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection.

ABSTRACT:

Background

Sensory disconnection is a key feature of sleep and anaesthesia. We have proposed that predictive coding offers a framework for understanding the mechanisms of disconnection. Low doses of ketamine that do not induce disconnection should thus diminish predictive coding, but not abolish it.

Methods

Ketamine was administered to 14 participants up to a blood concentration of 0.3 μg ml^-1 Participants were played a series of tones comprising a roving oddball sequence while electroencephalography evoked response potentials were recorded. We fit a Bayesian observer model to the tone sequence, correlating neural activity with the prediction errors generated by the model using linear mixed effects models and cluster-based statistics.

Results

Ketamine modul

SUBMITTER: Wehrman JJ 

PROVIDER: S-EPMC10624770 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature