A self-healable and bioadhesive acacia gum polysaccharide-based injectable hydrogel for wound healing acceleration.

ABSTRACT: The present study aimed at developing an injectable hydrogel based on acacia gum (AG) for wound healing acceleration. The hydrogels were synthetized through metal-ligand coordination mediated by Fe³⁺ and characterized in terms of gelation time, gel content, initial water content, swelling capacity, water retention ratio, and porosity. Moreover, FTIR, XRD and TGA analyses were performed for the hydrogels and allantoin (Alla) loaded ones. Furthermore, bioadhessiveness, and self-healing as well as antibacterial, toxicity and wound healing potentials of the hydrogels were evaluated. The hydrogels displayed fast gelation time, high swelling, porosity, and bioadhessiveness, as well as antioxidant, self-healing, antibacterial, blood clotting, and injectability properties. FTIR, XRD and

SUBMITTER: Ahmadian Z 

PROVIDER: S-EPMC10624782 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature