Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1.

ABSTRACT: Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infection is known to affect the NK cell pool, the additional impact of SARS-CoV-2 infection and/or vaccination on NK cell responses in people living with HIV (PLWH) has remained unexplored. Our data show that SARS-CoV-2 infection skews NK cells towards a more differentiated/adaptive CD57⁺FcεRIγ^- phenotype in PLWH. A similar subset was induced following vaccination in SARS-CoV-2 naïve PLWH in addition to a CD56^bright population with cytotoxic potential. Antibody-dependent NK cell function showed robust and durable responses to

SUBMITTER: Alrubayyi A 

PROVIDER: S-EPMC10624865 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature