Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity.

ABSTRACT: It is important for allocation of resources to predict those COVID patients at high risk of dying or organ failure. Early signals to initiate cellular events of host immunity can be derived from essential fatty acid metabolites preceding the cascade of proinflammatory signals. Much research has focused on understanding later proinflammatory responses. We assessed if remodelling of plasma phospholipid content of essential fatty acids by the COVID-19 virus provides early markers for potential death and disease severity. Here we show that, at hospital admission, COVID-19 infected subjects who survive exhibit higher proportions of C20:4n-6 in plasma phospholipids concurrent with marked proinflammatory cytokine elevation in plasma compared to healthy subjects. In contrast, more than half of sub

SUBMITTER: Mazurak VC 

PROVIDER: S-EPMC10624896 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature