Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated.

ABSTRACT: The dramatic changes in gene expression required for development necessitate the establishment of cis-regulatory modules defined by regions of accessible chromatin. Pioneer transcription factors have the unique property of binding closed chromatin and facilitating the establishment of these accessible regions. Nonetheless, much of how pioneer transcription factors coordinate changes in chromatin accessibility during development remains unknown. To determine whether pioneer-factor function is intrinsic to the protein or whether pioneering activity is developmentally modulated, we studied the highly conserved, essential transcription factor Grainy head (Grh). Prior work established that Grh is expressed throughout Drosophila development and is a pioneer factor in the larva. We

SUBMITTER: Nevil M 

PROVIDER: S-EPMC10624965 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature