Dataset Information

Amphiphilic Polymer Capped Perovskite Compositing with Nano Zr-MOF for Nanozyme-Involved Biomimetic Cascade Catalysis.

ABSTRACT: CsPbX₃ perovskite nanocrystal (NC) is considered as an excellent optical material and is widely applied in optoelectronics. However, its poor water stability impedes its study in enzyme-like activity, and further inhibits its application in biomimetic cascade catalysis. Herein, for the first time, the oxidase-like and ascorbate oxidase-like activities of an amphiphilic polymer capped CsPbX₃ are demonstrated, and its catalytic mechanism is further explored. Furthermore, an all-nanozyme cascade system (multifunctional CsPbBr₃ @Zr-metal organic framework (Zr-MOF) and Prussian blue as oxidase-like and peroxidase-like nanozyme) is constructed with a portable paper-based device for realizing the dual-mode (ratiometric fluorescence and colorimetric) detection of ascorbic acid in a point-of-care (POC) fashion. This is the first report on the utilization of all-inorganic CsPbX₃ perovskite NC in biomimetic cascade catalysis, which opens a new avenue for POC clinical disease diagnosis.

SUBMITTER: Ye Q

PROVIDER: S-EPMC10625115 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Amphiphilic Polymer Capped Perovskite Compositing with Nano Zr-MOF for Nanozyme-Involved Biomimetic Cascade Catalysis.

Ye Qiuyu Q Yuan Enxian E Shen Jin J Ye Mingli M Xu Qin Q Hu Xiaoya X Shu Yun Y Pang Huan H

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230827 31

CsPbX<sub>3</sub> perovskite nanocrystal (NC) is considered as an excellent optical material and is widely applied in optoelectronics. However, its poor water stability impedes its study in enzyme-like activity, and further inhibits its application in biomimetic cascade catalysis. Herein, for the first time, the oxidase-like and ascorbate oxidase-like activities of an amphiphilic polymer capped CsPbX<sub>3</sub> are demonstrated, and its catalytic mechanism is further explored. Furthermore, an a ...[more]

PMID: 37635202

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Project description:The management of diabetic ulcer (DU) to rescue stalled wound healing remains a paramount clinical challenge due to the spatially and temporally coupled pathological wound microenvironment that features hyperglycemia, biofilm infection, hypoxia and excessive oxidative stress. Here we present a pH-switchable nanozyme cascade catalysis (PNCC) strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in DU. The PNCC is demonstrated by employing the nanozyme of clinically approved iron oxide nanoparticles coated with a shell of glucose oxidase (Fe3O4-GOx). The Fe3O4-GOx possesses intrinsic glucose oxidase (GOx), catalase (CAT) and peroxidase (POD)-like activities, and can catalyze pH-switchable glucose-initiated GOx/POD and GOx/CAT cascade reaction in acidic and neutral environment, respectively. Specifically, the GOx/POD cascade reaction generating consecutive fluxes of toxic hydroxyl radical spatially targets the acidic biofilm (pH ~ 5.5), and eradicates biofilm to shorten the inflammatory phase and initiate normal wound healing processes. Furthermore, the GOx/CAT cascade reaction producing consecutive fluxes of oxygen spatially targets the neutral wound tissue, and accelerates the proliferation and remodeling phases of wound healing by addressing the issues of hyperglycemia, hypoxia, and excessive oxidative stress. The shortened inflammatory phase temporally coupled with accelerated proliferation and remodeling phases significantly speed up the normal orchestrated wound-healing cascades. Remarkably, this Fe3O4-GOx-instructed spatial-temporal remodeling of DU microenvironment enables complete re-epithelialization of biofilm-infected wound in diabetic mice within 15 days while minimizing toxicity to normal tissues, exerting great transformation potential in clinical DU management. The proposed PNCC concept offers a new perspective for complex pathological microenvironment remodeling, and may provide a powerful modality for the treatment of microenvironment-associated diseases.

Dataset Information

Amphiphilic Polymer Capped Perovskite Compositing with Nano Zr-MOF for Nanozyme-Involved Biomimetic Cascade Catalysis.

Publications

Amphiphilic Polymer Capped Perovskite Compositing with Nano Zr-MOF for Nanozyme-Involved Biomimetic Cascade Catalysis.

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