Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance.

ABSTRACT:

Background

Follicular thyroid cancer (FTC) is a prevalent form of differentiated thyroid cancer, whereas anaplastic thyroid cancer (ATC) represents a rare, fast-growing, undifferentiated, and highly aggressive tumor, posing significant challenges for eradication. Ferroptosis, an iron-dependent cell death mechanism driven by the excessive production of reactive oxygen species and subsequent lipid peroxidation, emerges as a promising therapeutic strategy for cancer. It has been observed that many cancer cells exhibit sensitivity to ferroptosis, while some other histotypes appear to be resistant, by counteracting the metabolic changes and oxidative stress induced by iron overload.

Methods

Here we used human biopsies and in vitro approaches to analyse the effects of iron-depende

SUBMITTER: D'Aprile S 

PROVIDER: S-EPMC10625232 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature