Ultrasound measurements of fetal facial profile markers and their associations with congenital malformations during early pregnancy.

ABSTRACT:

Background

Fetal facial profile could be measured during the early pregnancy. Its abnormalities might be associated with certain congenital malformations. We aimed to study the associations between fetal facial profile measurements with crown-rump length and congenital malformations (cleft lip and palate, micrognathia, and open spina bifida) during early pregnancy.

Methods

We performed a prospective cross-sectional study between June 2019 and April 2022. Pregnant women at a gestational age between 11-13^+ 6 weeks were enrolled. Two sonographers performed fetal facial profile measurements independently. The associations between these measurements with crown-rump length and congenital malformations were evaluated.

Results

There were 406 and 25 fetuses without

SUBMITTER: Liao M 

PROVIDER: S-EPMC10625258 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature