Molecular epidemiology and phylodynamic analysis of enterovirus 71 in Beijing, China, 2009-2019.

ABSTRACT:

Background

Enterovirus 71(EV71)-associated hand, foot and mouth disease (HFMD) decreased dramatically in Beijing from 2009 to 2019. This study was to investigate the epidemiological characteristics, evolutionary dynamics, geographic diffusion pathway, and other features of EV71 in Beijing, China.

Methods

We conducted a retrospective study of EV71-associated HFMD and its causative agent in Beijing, China, from 2009 to 2019. Phylogenetic and phylogeographic methods based on the EV71 genome were used to determine the evolution features, origin, and spatiotemporal dynamics. Positive selection sites in the VP1 gene were identified and exhibited in the tertiary structure. Bayesian birth-death skyline model was used to estimate the effective reproductive number (Re).

Results

SUBMITTER: Li J 

PROVIDER: S-EPMC10625277 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature