Development of a cortical delay discounting assay: a potential biomarker of externalizing disorders.

ABSTRACT:

Background

People who tend to impulsively choose smaller, sooner rewards over larger, later rewards are at increased risk for addiction and psychiatric disorders. A neurobiological measure of the tendency to overvalue immediate gratification could facilitate the study of individuals who are susceptible to these mental disorders. The objective of this research was to develop a cortical assay of impulsive choice for immediate rewards.

Methods

A cortex-based assay of impulsive choice was developed using 1105 healthy adults from the Human Connectome Project, and then cross-validated in two independent samples of adults with elevated rates of psychiatric disorders.

Results

Study 1: Cortical delay discounting (C-DD) was developed using a multivariate additive model o

SUBMITTER: Sadeh N 

PROVIDER: S-EPMC10625335 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature