A benzochalcone derivative synchronously induces apoptosis and ferroptosis in pancreatic cancer cells.

ABSTRACT:

Background

Pancreatic cancer is a highly aggressive and lethal disease with limited treatment options. In this study, we investigated the potential therapeutic effects of compound KL-6 on pancreatic cancer cells.

Methods

The study involved assessing the inhibitory effects of KL-6 on cell proliferation, clonogenic potential, cell cycle progression, apoptosis, migration, and invasion. Additionally, we examined the action mechanism of KL-6 by RNA-seq and bioinformatic analysis and validated by qRT-PCR and western blot in pancreatic cancer cells.

Results

Our results demonstrated that KL-6 effectively inhibited the growth of pancreatic cancer cells in a dose-dependent manner. It induced G2/M phase cell cycle arrest and apoptosis, disrupting the cell cycle progression and p

SUBMITTER: Guan X 

PROVIDER: S-EPMC10625348 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature