Identification of Ferroptosis-Related Genes in Heart Failure Induced by Transverse Aortic Constriction.

ABSTRACT:

Background

Heart failure (HF) is a common clinical syndrome due to ventricular dysfunction and is a major cause of mortality worldwide. Ferroptosis, marked by excessive iron-dependent lipid peroxidation, is closely related to HF. Therefore, the purpose of this study is to explore and validate ferroptosis-related markers in HF by bioinformatics analysis and animal experiments validation.

Materials and methods

The gene expression profiles (GSE36074) of murine transverse aortic constriction (TAC) were obtained from the Gene Expression Omnibus (GEO); From the FerrDb database, ferroptosis-related genes (FRGs) were identified. Using GEO2R, differential expressed genes (DEGs) were screened. An overlapping analysis was conducted among DEGs and FRGs to identify ferroptosis-related DE

SUBMITTER: Gu JJ 

PROVIDER: S-EPMC10625389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature