NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer.

ABSTRACT:

Significance

Cancer cells accumulate high levels of iron and reactive oxygen species (ROS) to promote their high metabolic activity and proliferation rate. However, high levels of iron and ROS can also lead to enhanced oxidative stress and the activation of cell death pathways such as apoptosis and ferroptosis. This has led to the proposal that different drugs that target iron and/or ROS metabolism could be used as anticancer drugs. However, due to the complex role iron and ROS play in cells, the majority of these drugs yielded mixed results, highlighting a critical need to identify new players in the regulation of iron and ROS homeostasis in cancer cells. Recent Advances: NEET proteins belong to a newly discovered class of iron-sulfur proteins (2Fe-2S) required for the regulation

SUBMITTER: Mittler R 

PROVIDER: S-EPMC10625470 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature