Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

Previous observational studies have explored the correlation between testosterone and cancer risk. However, the causal association between testosterone and various cancer types in women remains inconclusive. The objective of this Mendelian randomization study is to evaluate the causal links between total testosterone (TT) and bioavailable testosterone (BT) with cancer risk in females.

Methods

Initially, a rigorous quality control process was employed to identify suitable instrumental single nucleotide polymorphisms (SNPs) associated with the exposure under investigation that exhibited a significant association. The genetic causal relationship between female testosterone levels and the risk of developing cancers was examined through a two-sample Mendelian randomizat

SUBMITTER: Li Z 

PROVIDER: S-EPMC10625503 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature