Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients.

ABSTRACT: Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. GBC and control tissue samples were sequenced for miRNA expression using the Illumina HiSeq platform. Biological processes and related pathways were determined using the Panther and Gene Ontology databases. 439 significantly differentially expressed miRNAs were identified; 19

SUBMITTER: Saxena R 

PROVIDER: S-EPMC10625549 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature