Polymer composite microspheres loading ¹⁷⁷Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer.

ABSTRACT:

Background

Transarterial radioembolization (TARE) with ⁹⁰Y-labeled glass and resin microspheres is one of the primary treatment strategies for advanced-stage primary and metastatic hepatocellular carcinoma (HCC). However, difficulties of real-time monitoring post administration and embolic hypoxia influence treatment prognosis. In this study, we developed a new biodegradable polymer microsphere that can simultaneously load ¹⁷⁷Lu and MgO nanoparticle, and evaluated the TARE therapeutic efficacy and biosafety of ¹⁷⁷Lu-PDA-CS-MgO microspheres for HCC treatment.

Methods

Chitosan microspheres were synthesized through emulsification crosslink reaction and then conducted surface modification with polydopamine (PDA). The ¹⁷⁷Lu and nano MgO

SUBMITTER: Xiao L 

PROVIDER: S-EPMC10625707 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature