The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex.

ABSTRACT: Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with classic slow signals related to brain and behavioral states and fast, phasic signals reflecting behavioral events, including movement, reinforcement and sensory-evoked responses. However, it remains unknown whether sensory cholinergic signals target the sensory cortex and how they relate to local functional topography. Here we used simultaneous two-channel, two-photon imaging of CBF axons and auditory cortical neurons to reveal that CBF axons send a robust, nonhabituating and stimulus-specific sensory signal to the auditory cortex. Individual axon segments exhibited heterogeneous but stable tuning to auditory stimuli allowing stimulus identity to be decoded from population activity. However, CBF axons

SUBMITTER: Zhu F 

PROVIDER: S-EPMC10625791 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature