Direct wire pacing during measurement of fractional flow reserve: A randomized proof-of-concept noninferiority crossover trial.

ABSTRACT:

Background

Adenosine administration for fractional flow reserve (FFR) measurement may induce heart pauses.

Aims

To assess the accuracy and tolerability of direct wire pacing (DWP) during measurement of FFR.

Methods

Adults with at least one intermediate coronary artery stenosis (40%-80%) were consecutively enrolled between June 2021 and February 2022 in this randomized, noninferiority, crossover trial (NCT04970082) carried out in France. DWP was applied (DWP) or not (standard method) through the pressure guidewire used for FFR measurement during adenosine-induced maximal hyperaemia. Subjects were randomly assigned to the allocation sequence (DWP first or standard first). A 2-minute washout period was observed between the two FFR measurements performed for each stenosis

SUBMITTER: Faurie B 

PROVIDER: S-EPMC10625906 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature