Design of a multi-epitope vaccine against brucellosis fused to IgG-fc by an immunoinformatics approach.

ABSTRACT:

Introduction

Brucella, a type of intracellular Gram-negative bacterium, has unique features and acts as a zoonotic pathogen. It can lead to abortion and infertility in animals. Eliminating brucellosis becomes very challenging once it spreads among both humans and animals, putting a heavy burden on livestock and people worldwide. Given the increasing spread of brucellosis, it is crucial to develop improved vaccines for susceptible animals to reduce the disease's impact.

Methods

In this study, we effectively used an immunoinformatics approach with advanced computer software to carefully identify and analyze important antigenic parts of Brucella abortus. Subsequently, we skillfully designed chimeric peptides to enhance the vaccine's strength and effectiveness. We

SUBMITTER: Wu A 

PROVIDER: S-EPMC10625910 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature