M⁶A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most common RNA modification in eukaryotic RNAs. Although the important roles of m⁶A in RNA fate have been revealed, the potential contribution of m⁶A to RNA function in various diseases, including hepatocellular carcinoma (HCC), is still unclear. In this study, we identified a novel m⁶A-modified RNA AC026356.1. We found that AC026356.1 was increased in HCC tissues and cell lines. High expression of AC026356.1 was correlated with poor survival of HCC patients. m⁶A modification level of AC026356.1 was also increased in HCC and more significantly correlated with poor survival of HCC patients. Functional assays showed that m⁶A-modified AC026356.1 promoted HCC cellular proliferation, mi

SUBMITTER: Wei H 

PROVIDER: S-EPMC10625930 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature