Prognostic Significance of Sentinel Lymph Node Status in Thick Primary Melanomas (> 4 mm).

ABSTRACT:

Background

The key prognostic factors for staging patients with primary cutaneous melanoma are Breslow thickness, ulceration, and sentinel lymph node (SLN) status. The multicenter selective lymphadenectomy trial (MSLT-I) verified SLN status as the most important prognostic factor for patients with intermediate-thickness melanoma (Breslow thickness, 1-4 mm). Although most international guidelines recommend SLN biopsy (SLNB) also for patients with thick (> 4 mm, pT4) melanomas, its prognostic role has been questioned. The primary aim of this study was to establish whether SLN status is prognostic in T4 melanoma tumors.

Methods

Data for all patients with a diagnosis of primary invasive cutaneous melanoma of Breslow thickness greater than 1 mm in Sweden between 2007 and 2020 wer

SUBMITTER: Holmberg CJ 

PROVIDER: S-EPMC10625939 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature