DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle.

ABSTRACT: Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein production. However, the coordination of these regulatory mechanisms to achieve such tissue-specific protein production remains unclear. Here, we analyzed the DNA methylome, transcriptome, and proteome in mouse liver and skeletal muscle. We found that DNA hypomethylation at promoter regions is globally associated with liver-dominant or skeletal muscle-dominant functional protein production within each tissue, as well as with genes encoding proteins involved in ubiquitous functions in both tissues. Thus, genes encoding liver-dominant proteins, such as those involved in glycolysis or gluconeo

SUBMITTER: Maehara H 

PROVIDER: S-EPMC10625943 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature