Prognostic Significance of Pathologic Lymph Node Invasion in Metastatic Renal Cell Carcinoma in the Immunotherapy Era.

ABSTRACT:

Background

This study aimed to test the prognostic significance of pathologically confirmed lymph node invasion in metastatic renal cell carcinoma (mRCC) patients in this immunotherapy era.

Methods

Surgically treated mRCC patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2018. Kaplan-Meier plots and multivariable Cox-regression models were fitted to test for differences in cancer-specific mortality (CSM) and overall mortality (OM) according to N stage (pN0 vs pN1 vs. pNx). Subgroup analyses addressing pN1 patients tested for CSM and OM differences according to postoperative systemic therapy status.

Results

Overall, 3149 surgically treated mRCC patients were identified. Of these patients, 443 (14%) were labeled

SUBMITTER: Scheipner L 

PROVIDER: S-EPMC10625944 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature