Liquid resistivity of pharmaceutical propellants using novel resistivity cell.

ABSTRACT: Metered-dose inhalers employ propellants to produce pharmaceutical aerosols for treating respiratory conditions like asthma. In the liquid phase, the DC volume resistivity of pharmaceutical propellants, including R134a, R152a, and R227ea, was studied at saturation pressures and room temperature (not vapour phase). These measurements are essential for industries like refrigerants. Aerosols from metered dose inhalers (MDIs) with these propellants become electrically charged, affecting medicament deposition in lung. The resistivity was measured using a novel concentric cylinder-type capacitance cell designed in-house. The resistivity for the propellants (R134a, R152a, and R227ea) was found to be 3.02 × 10¹⁰ Ωm, 2.37 × 10⁹ Ωm and 1.31 × 10¹⁰ Ωm, respectively. T

SUBMITTER: Ahmad H 

PROVIDER: S-EPMC10625955 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature