Limited cumulative experience with ex vivo lung perfusion is associated with inferior outcomes after lung transplantation.

ABSTRACT:

Objective

Ex vivo lung perfusion (EVLP) allows for prolonged preservation and evaluation/resuscitation of donor lungs. We evaluated the influence of center experience with EVLP on lung transplant outcomes.

Methods

We identified 9708 isolated, first-time adult lung transplants from the United Network for Organ Sharing database (March 1, 2018-March 1, 2022), 553 (5.7%) involved using donor lungs after EVLP. Using the total volume of EVLP lung transplants per center during the study period, centers were dichotomized into low- (1-15 cases) and high-volume (>15 cases) EVLP centers.

Results

Forty-one centers performed EVLP lung transplants, including 26 low-volume and 15 high-volume centers (median volume, 3 vs 23 cases; P < .001). Recipients at low-volume centers (n = 109)

SUBMITTER: Chen Q 

PROVIDER: S-EPMC10626047 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature