IHypoxia: An Integrative Database of Protein Expression Dynamics in Response to Hypoxia in Animals.

ABSTRACT: Mammals have evolved mechanisms to sense hypoxia and induce hypoxic responses. Recently, high-throughput techniques have greatly promoted global studies of protein expression changes during hypoxia and the identification of candidate genes associated with hypoxia-adaptive evolution, which have contributed to the understanding of the complex regulatory networks of hypoxia. In this study, we developed an integrated resource for the expression dynamics of proteins in response to hypoxia (iHypoxia), and this database contains 2589 expression events of 1944 proteins identified by low-throughput experiments (LTEs) and 422,553 quantitative expression events of 33,559 proteins identified by high-throughput experiments from five mammals that exhibit a response to hypoxia. Various experimental detai

SUBMITTER: Liu ZX 

PROVIDER: S-EPMC10626056 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature