Advances in Anti-obesity Pharmacotherapy: Current Treatments, Emerging Therapies, and Challenges.

ABSTRACT: Obesity is a major public health concern linked to health risks such as hypertension, hyperlipidemia, type 2 diabetes mellitus (T2DM), stroke, metabolic syndrome, asthma, and cancer. It is among the leading causes of morbidity and mortality worldwide caused by an unhealthy diet and lack of physical activity, but genetic or hormonal factors may also contribute. Over a third of adults in the United States are obese. Pharmacological agents have been designed to reduce weight gain caused by excessive calorie intake and low physical activity. They work by inhibiting the absorption of dietary fat or stimulating the secretion of satiety hormones. These drugs include lipase inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists. However, the current weight-loss strategies do not effectiv

SUBMITTER: Brandfon S 

PROVIDER: S-EPMC10626572 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature