Complex Conformational Space of the RNA Polymerase II C-Terminal Domain upon Phosphorylation.

ABSTRACT: Intrinsically disordered proteins (IDPs) have been closely studied during the past decade due to their importance in many biological processes. The disordered nature of this group of proteins makes it difficult to observe its full span of the conformational space using either experimental or computational studies. In this article, we explored the conformational space of the C-terminal domain (CTD) of RNA polymerase II (Pol II), which is also an intrinsically disordered low complexity domain, using enhanced sampling methods. We provided a detailed conformational analysis of model systems of CTD with different lengths; first with the last 44 residues of the human CTD sequence and finally the CTD model with 2-heptapeptide repeating units. We then investigated the effects of phosphorylation on

SUBMITTER: Amith WD 

PROVIDER: S-EPMC10626582 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature