Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: An epigenetics pilot study.

ABSTRACT: Maternal sleep and circadian health during pregnancy are emerging as important predictors of pregnancy outcomes, but examination of potential epigenetic mechanisms is rare. We investigated links between maternal leukocyte DNA methylation of circadian genes and birth outcomes within a pregnancy cohort. Women (n = 96) completed a questionnaire and provided a blood sample at least once during early-to-mid pregnancy (average gestation weeks = 14.2). Leukocyte DNA was isolated and DNA methylation (average percent of methylation) at multiple CpG sites within BMAL1, PER1, and MTNR1B genes were quantified by pyrosequencing. Birth outcomes including gestational age at delivery, birthweight, and head circumference were abstracted from medical charts. Linear regression ana

SUBMITTER: Jansen EC 

PROVIDER: S-EPMC10626590 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature