Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS.

ABSTRACT:

Background

Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have been demonstrated to play an important role in the development of oligodendrocytes, the myelin producing cells in the CNS, as well as in myelination. Mertk is a receptor expressed on microglia that mediates immunoregulatory functions, including myelin efferocytosis.

Findings

Here we demonstrate an unexpected role for Mertk-expressing microglia in both oligodendrogenesis and myelination. The selective depletion of Mertk from microglia resulted in reduced oligodendrocyte production in early development and the generation of pathological myelin. During demyelinat

SUBMITTER: Nguyen LT 

PROVIDER: S-EPMC10626688 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature