Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice.

ABSTRACT:

Background

Allergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq, we found that asthmatic lungs display lower levels of Isthmin-1 (ISM1) expression than healthy lungs. ISM1 is an endogenous anti-inflammatory protein that is highly expressed in mouse lungs and bronchial epithelial cells, playing a crucial role in maintaining lung homeostasis. However, how ISM1 influences asthma remains unclear. This study aims to investigate the potential involvement of ISM1 in allergic airway inflammation and uncover the underlying mechanisms.

Methods

We investigated the pivotal role of ISM1 in airway inflammation using an ISM1 knockout mouse line (ISM1^-/-) and challenged them with house dust mite (

SUBMITTER: Tee JH 

PROVIDER: S-EPMC10626717 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature