Fluid balance control in critically ill patients: results from as-treated analyses of POINCARE-2 randomized trial.

ABSTRACT:

Background

Intention-to-treat analyses of POINCARE-2 trial led to inconclusive results regarding the effect of a conservative fluid balance strategy on mortality in critically ill patients. The present as-treated analysis aimed to assess the effectiveness of actual exposure to POINCARE-2 strategy on 60-day mortality in critically ill patients.

Methods

POINCARE‑2 was a stepped wedge randomized controlled trial. Eligible patients were ≥ 18 years old, under mechanical ventilation and had an expected length of stay in ICU > 24 h. POINCARE-2 strategy consisted of daily weighing over 14 days, and subsequent restriction of fluid intake, administration of diuretics, and/or ultrafiltration. We computed a score of exposure to the strategy based on deviations from the strategy algorith

SUBMITTER: Mansouri A 

PROVIDER: S-EPMC10626740 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature