Serum neurofilament light chain levels in migraine patients: a monocentric case-control study in China.

ABSTRACT:

Purpose

Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine.

Methods

A case-control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics.

Results

Overall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than i

SUBMITTER: Fang J 

PROVIDER: S-EPMC10626745 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature