A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence.

ABSTRACT:

Background

The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a lifetime exposure to antigens results in structural and functional changes of the lung; yet an understanding of the cell type specific responses remains elusive. To gain insight into age-related changes in lung function and inflammaging, we evaluated 89 mouse and 414 individual human lung genomic data sets with a focus on genes mechanistically linked to extracellular matrix (ECM), cellular senescence, immune response and pulmonary surfactant, and we interrogated single cell RNAseq data to fingerprint cell type specific changes.

Results

We identified 117 and 68 mouse and human genes linked to ECM remodeling which accounted for 46%

SUBMITTER: He M 

PROVIDER: S-EPMC10626779 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature