Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space.

ABSTRACT:

Background

Preliminary evidence suggests that several headache disorders may be associated with glymphatic dysfunction. However, no studies have been conducted to examine the glymphatic activity in migraine chronification.

Purposes

To investigate the glymphatic activity of migraine chronification in patients with episodic migraine (EM) and chronic migraine (CM) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method.

Methods

In this cross-sectional study, patients with EM, CM, and healthy controls (HCs) were included. All participants underwent a standard brain magnetic resonance imaging (MRI) examination. Bilateral DTI-ALPS indexes were calculated for all participants and compared among EM, CM, and HC groups. Correlations between the

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10626803 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature